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Rabbit Anti-GLUT4/Biotin Conjugated antibody (bs-0384R-Bio)
訂購熱線:400-901-9800
訂購郵箱:[email protected]
訂購傳真:010-58129612
技術支持:[email protected]
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-0384R-Bio
英文名稱 Anti-GLUT4/Biotin
中文名稱 生物素標記的葡萄糖轉運蛋白4抗體
別    名 insulin-responsive; Glucose transporter GLUT 4; Glucose Transporter GLUT4; Glucose transporter type 4; Glucose transporter type 4 insulin responsive; GLUT 4; GLUT-4; GLUT4; GTR4_HUMAN; kug; SLC 2A4; SLC2A4; solute carrier family 2 (facilitated glucose transporter) member 4; Solute carrier family 2, facilitated glucose transporter member 4.  
規格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  心血管  免疫學  信號轉導  干細胞  糖尿病  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep, 
產品應用 WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 54kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GLUT4
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
GLUT4 is the facilitated glucose transporter expressed exclusively in adipocytes and muscle cells, and is also known as the "insulin-responsive" glucose transporter. GLUT4 translocates from an ill-defined intracellular compartment to the plasma membrane in response to insulin. The total cellular content of GLUT4 is significantly decreased in adipose cells from many patients with Type II diabetes mellitus, and animals with some types of experimental diabetes.

Function:
Insulin-regulated facilitative glucose transporter.

Subcellular Location:
Endomembrane system. Cytoplasm > perinuclear region. Localizes primarily to the perinuclear region, undergoing continued recycling to the plasma membrane where it is rapidly reinternalized. The dileucine internalization motif is critical for intracellular sequestration.

Tissue Specificity:
Skeletal and cardiac muscles; brown and white fat.

Post-translational modifications:
Sumoylated.

DISEASE:
Defects in SLC2A4 may be a cause of noninsulin-dependent diabetes mellitus (NIDDM) [MIM:125853]. Defects in SLC2A4 may be a cause of certain post-receptor defects in NIDDM. The variant in position Ile-383 is found in a small number of NIDDM patients, but seems not to be found in nondiabetic subjects.

Similarity:
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.

Database links:

Entrez Gene: 282359 Cow

Entrez Gene: 6517 Human

Entrez Gene: 20528 Mouse

Entrez Gene: 25139 Rat

Omim: 138190 Human

SwissProt: Q27994 Cow

SwissProt: Q29RP5 Cow

SwissProt: P14672 Human

SwissProt: P14142 Mouse

SwissProt: P19357 Rat

Unigene: 380691 Human

Unigene: 10661 Mouse

Unigene: 1314 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

葡萄糖轉運蛋白-4是一種十分重要的葡萄糖轉運體,與胰島素抵抗和2型糖尿病密切相關.葡萄糖轉運蛋白4在細胞內部和細胞膜之間循環流動.實現對葡萄糖的轉運需要葡萄糖轉運蛋白4自身的轉位和活化.葡萄糖轉運蛋白4與肥胖、腫瘤相關聯.
GLUT-2和GLUT-4蛋白這兩個葡萄糖運載體的研究對于糖尿病的胰島素釋放障礙和胰島素抵抗有重要意義.
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