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Rabbit Anti-TPH antibody (bs-1215R)
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說明書: 50ul  100ul  200ul
50ul/980.00元
100ul/1680.00元
200ul/2480.00元
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產品編號 bs-1215R
英文名稱 TPH
中文名稱 色氨酸羥化酶抗體
別    名 MGC119994; TPH 1; TPH; TPH1; TPRH; Tryptophan 5 hydroxylase 1; Tryptophan 5 monooxygenase 1; Tryptophan 5 monooxygenase; Tryptophan hydroxylase 1; Tryptophan 5-hydroxylase 1; TPH1_HUMAN.  
Specific References  (1)     |     bs-1215R has been referenced in 1 publications.
[IF=2.75] Dong, Xian-Zhe, et al. "A representative prescription for emotional disease, Ding-Zhi-Xiao-Wan restores 5-HT system deficit through interfering the synthesis and transshipment in chronic mild stress-induced depressive Rats." Journal of Ethnopharmacology (2013).  WB ;  Rat.  
研究領域 細胞生物  神經生物學  信號轉導  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, Chicken, Dog, Horse, Rabbit, 
產品應用 WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 49kDa
細胞定位 細胞漿 
性    狀 Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TPH:31-150/444 
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMed PubMed
產品介紹 This gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others.[provided by RefSeq, Apr 2009].

Subunit:
Homotetramer.

Tissue Specificity:
Isoform 2 seems to be less widely expressed than isoform 1.

Similarity:
Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
Contains 1 ACT domain.

SWISS:
P17752

Gene ID:
7166

Database links:

Entrez Gene: 7166 Human

Entrez Gene: 21990 Mouse

Entrez Gene: 24848 Rat

Omim: 191060 Human

SwissProt: P17752 Human

SwissProt: P17532 Mouse

SwissProt: P09810 Rat

Unigene: 591999 Human

Unigene: 248684 Mouse

Unigene: 94788 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

色氨酸在腦中首先由色氨酸羥化酶(tryoptophan hydroxylase)催化生成5羥色氨酸(5hydroxytryptophan),再經脫羧酶作用生成5羥色胺,色氨酸羥化酶(TPH)是5-HT生物合成的限速酶,因此,色氨酸羥化酶的缺少可導致5-羥色胺的含量下降。色氨酸羥化酶主要在肝臟內代謝。
產品圖片
Sample: Liver (Mouse)Lysate at 40 ug
Primary: Anti-TPH(bs-1215R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 49 kD
Observed band size: 49kD
Sample: Lung (Mouse)Lysate at 40 ug
Primary: Anti-TPH(bs-1215R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 49 kD
Observed band size: 49kD
Sample: HL60/HepG2/K562 Cell Lysate at 40 ug
Primary: Anti- TPH(bs-1215R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 49 kD
Observed band size: 53kD
Sample: HL60/HepG2/K562 Cell Lysate at 40 ug
Primary: Anti- TPH(bs-1215R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 49 kD
Observed band size: 54 kD
Sample:
Heart (Rat) Lysate at 40 ug
Primary: Anti-TPH (bs-1215R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 49 kD
Observed band size: 49 kD
Paraformaldehyde-fixed, paraffin embedded (Rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (TPH) Polyclonal Antibody, Unconjugated (bs-1215R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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